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By targeting both GLP-1 and GIP receptors, tirzepatide enhances insulin secretion and reduces glucagon secretion in a glucose-dependent manner, which helps improve glycemic control

This inhibition then translates into an observed reduction in the astrocytic release of IL-6 and monocyte chemoattractant protein-1 (MCP-1) in primary human cell cultures, thereby reducing inflammatory signaling and peripheral immune cell recruitment, respectively (Rizzo et al., 2019

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L-Carnitine may also support normal ventricular function and superoxide dismutase enzyme activity

Salt forms of semaglutide are problematic